Shattering the Water Window: Comprehensive Mapping of Faradaic Reactions on Bioelectronics Electrodes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F24%3APU152633" target="_blank" >RIV/00216305:26620/24:PU152633 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/24:00139038
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsami.4c12268" target="_blank" >https://pubs.acs.org/doi/10.1021/acsami.4c12268</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsami.4c12268" target="_blank" >10.1021/acsami.4c12268</a>
Alternative languages
Result language
angličtina
Original language name
Shattering the Water Window: Comprehensive Mapping of Faradaic Reactions on Bioelectronics Electrodes
Original language description
It is generally accepted that for safe use of neural interface electrodes, irreversible faradaic reactions should be avoided in favor of capacitive charge injection. However, in some cases, faradaic reactions can be desirable for controlling specific (electro)physiological outcomes or for biosensing purposes. This study aims to systematically map the basic faradaic reactions occurring at bioelectronic electrode interfaces. We analyze archetypical platinum-iridium (PtIr), the most commonly used electrode material in biomedical implants. By providing a detailed guide to these reactions and the factors that influence them, we offer a valuable resource for researchers seeking to suppress or exploit faradaic reactions in various electrode materials. We employed a combination of electrochemical techniques and direct quantification methods, including amperometric, potentiometric, and spectrophotometric assays, to measure O-2, H-2, pH, H2O2, Cl-2/OCl-, and soluble platinum and iridium ions. We compared phosphate-buffered saline (PBS) with an unbuffered electrolyte and complex cell culture media containing proteins. Our results reveal that the "water window" the potential range without significant water electrolysis varies depending on the electrolyte used. In the culture medium that is rich with redox-active species, a window of potentials where no faradaic process occurs essentially does not exist. Under cathodic polarizations, significant pH increases (alkalization) were observed, while anodic water splitting competes with other processes in media, preventing prevalent acidification. We quantified the oxygen reduction reaction and accumulation of H2O2 as a byproduct. PtIr efficiently deoxygenates the electrolyte under low cathodic polarizations, generating local hypoxia. Under anodic polarizations, chloride oxidation competes with oxygen evolution, producing relatively high and cytotoxic concentrations of hypochlorite (OCl-) under certain conditions. These oxidative proce
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21000 - Nano-technology
Result continuities
Project
<a href="/en/project/GA23-07432S" target="_blank" >GA23-07432S: Faraday’s Scalpel: electrochemical oxygen reduction for precise neural tissue ablation</a><br>
Continuities
—
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS applied materials & interfaces
ISSN
1944-8244
e-ISSN
1944-8252
Volume of the periodical
16
Issue of the periodical within the volume
40
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
53567-53576
UT code for WoS article
001326721500001
EID of the result in the Scopus database
2-s2.0-85205793842