In Vivo Assessment on Freeze-Cast Calcium Phosphate-Based Scaffolds with a Selective Cell/Tissue Ingrowth
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F24%3APU152634" target="_blank" >RIV/00216305:26620/24:PU152634 - isvavai.cz</a>
Alternative codes found
RIV/68081723:_____/24:00600314 RIV/60162694:G44__/25:00563882 RIV/62156489:43210/24:43926031
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsami.4c12715" target="_blank" >https://pubs.acs.org/doi/10.1021/acsami.4c12715</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsami.4c12715" target="_blank" >10.1021/acsami.4c12715</a>
Alternative languages
Result language
angličtina
Original language name
In Vivo Assessment on Freeze-Cast Calcium Phosphate-Based Scaffolds with a Selective Cell/Tissue Ingrowth
Original language description
Highly porous bioceramic scaffolds are widely used as bone substitutes in many applications. However, the use of bioceramics is often limited to hard tissues due to the risk of potential soft tissue calcification. A further limitation of highly porous bioceramic scaffolds is their poor mechanical stability, manifested by their tendency to break under stress. In our study, highly porous CaP-based scaffolds were prepared via freeze-casting with longitudinal and oriented pores ranging from 10 to 20 mu m and a relative porosity of similar to 70%. The resulting scaffolds achieved a flexural strength of 10.6 +/- 2.7 MPa, which, in conjunction with their favorable bioactivity, made them suitable for in vivo testing. The prepared scaffolds were subcutaneously implanted in rats for two distinct periods: 6 weeks and 6 months, respectively. The subsequent development of fibrous tissue and involvement of myofibroblasts, newly formed vessels, and macrophages were observed, with notable changes in spatial and temporal distributions within the implantation. The absence of calcification in the surrounding soft tissue, as a result of the narrow pore geometry, indicates the opportunity to tailor the scaffold behavior for soft tissue regeneration.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21000 - Nano-technology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS APPL MATER INTER
ISSN
1944-8244
e-ISSN
1944-8252
Volume of the periodical
16
Issue of the periodical within the volume
43
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
58326-58336
UT code for WoS article
001338424100001
EID of the result in the Scopus database
2-s2.0-85206924930