Bone Response to Biodegradable Metals and In Vitro Evaluation of the Cytocompatibility
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F26%3A0197800" target="_blank" >RIV/00216305:26620/26:0197800 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s11837-025-07353-8" target="_blank" >https://link.springer.com/article/10.1007/s11837-025-07353-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11837-025-07353-8" target="_blank" >10.1007/s11837-025-07353-8</a>
Alternative languages
Result language
angličtina
Original language name
Bone Response to Biodegradable Metals and In Vitro Evaluation of the Cytocompatibility
Original language description
This review focuses on the bone response to biodegradable metals used in temporary osteosynthesis devices. These implants are designed to degrade in vivo, fully dissolving after stabilizing fractures, osteotomies, and ligament fixations, thus eliminating the need for a second surgery. The review delves into the interactions between biodegradable metallic implants and bone tissue, emphasizing the bidirectional nature of this process. It covers the families of biodegradable metals and their degradation mechanisms, with particular attention paid to the time-dependence of the foreign body reaction and the local sterile inflammation response. Additionally, the review discusses current in vitro methods for evaluating biological safety, osteogenic properties, and inflammatory responses. The limitations of traditional cell culture models in replicating the in vivo bone environment are discussed, along with recent advancements in the field. The review concludes by proposing strategies to control the degradation of biodegradable metals and more accurately replicate bone tissue, which could potentially enable more precise in vitro degradation and biological characterization, reducing reliance on in vivo experiments.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20500 - Materials engineering
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOM
ISSN
1047-4838
e-ISSN
1543-1851
Volume of the periodical
77
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
20
Pages from-to
4473-4492
UT code for WoS article
001470066000001
EID of the result in the Scopus database
2-s2.0-105003409557