Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F12%3A10135327" target="_blank" >RIV/00669806:_____/12:10135327 - isvavai.cz</a>

Result on the web

<a href="http://www.nature.com/bmt/journal/v47/n5/pdf/bmt2011156a.pdf" target="_blank" >http://www.nature.com/bmt/journal/v47/n5/pdf/bmt2011156a.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/bmt.2011.156" target="_blank" >10.1038/bmt.2011.156</a>

Result language

angličtina

Original language name

Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT

Original language description

Oral cavity cooling (cryotherapy) provided during high-dose melphalan bolus or short-infusion administration contributes to local vasoconstriction, lower blood circulation, lower local cytotoxic drug exposure and significantly reduced oral mucositis (OM)incidence.1-3 OM is a significant posttransplant complication, and together with gut tissue damage and inflammation, caused by conditioning regimens, contributes to the development and pathogenesis of acute GVHD.4-6 The incidence of acute GVHD varies between 28 and 45% in the Flu/Mel-reduced intensity conditioning regimen comprising of fludarabine total dose 125-150mg/m2 and melphalan total dose 140-180mg/m2.1,7-9 We decided to analyze the impact of reduced OMincidence (reduced oral tissue damage) on acute GVHD, and analyzed 142 prospectively observed patients after Flu/Mel (fludarabine 30mg/m2 i.v. once daily for 4 days, melphalan 140mg/m2 i.v. one day before transplantation) allo-SCT performed at our institution from January 2005 to

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bone Marrow Transplantation

ISSN

0268-3369

e-ISSN

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Volume of the periodical

47

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

3

Pages from-to

739-741

UT code for WoS article

000303923500021

EID of the result in the Scopus database

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