Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F13%3A10145795" target="_blank" >RIV/00669806:_____/13:10145795 - isvavai.cz</a>

Result on the web

<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874498/pdf/WJD-4-372.pdf" target="_blank" >http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874498/pdf/WJD-4-372.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4239/wjd.v4.i6.372" target="_blank" >10.4239/wjd.v4.i6.372</a>

Result language

angličtina

Original language name

Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers

Original language description

AIM To examine skin perfusion in dependency on insulinemia in healthy subjects. METHODS: All volunteers were informed in detail about the procedures and signed informed consent. The protocol of this study was approved by ethical committee. In our study atwo-stage hyperinsulinemic euglycaemic clamp was performed, with insulinemia 100 and 250 mIU/mL and glycaemia 5.0 mmol/L (3% standard deviation). Before the clamp and in steady states, microcirculation was measured by laser-doppler flowmetry and transcutaneous oximetry and energy expenditure was measured by indirect calorimetry. Results (average and standard deviation) were evaluated with paired t-test. RESULTS: Physiological (50 mIU/L) insulinemia leaded to higher perfusion in both tests- hyperemia after heating to 44 oC- 1848% (984 - 2046) vs 1599% (801 - 1836), P < 0.05, half time of reaching peak perfusion after occlusion release 1.2 s (0.9 - 2.6) vs 4.9 s (1.8 - 11.4), P < 0.05. Supraphysiological (150 mIU/L) insulinemia leaded to

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

World Journal of Diabetes

ISSN

1948-9358

e-ISSN

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Volume of the periodical

4

Issue of the periodical within the volume

6

Country of publishing house

CN - CHINA

Number of pages

6

Pages from-to

372-377

UT code for WoS article

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EID of the result in the Scopus database

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