Serum citrulline levels as a marker of enterocyte function in patients after allogeneic hematopoietic stem cells transplantation - a pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F13%3A10209983" target="_blank" >RIV/00669806:_____/13:10209983 - isvavai.cz</a>

Result on the web

<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628888/pdf/medscimonit-19-81.pdf" target="_blank" >http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628888/pdf/medscimonit-19-81.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.12659/MSM.883755" target="_blank" >10.12659/MSM.883755</a>

Result language

angličtina

Original language name

Serum citrulline levels as a marker of enterocyte function in patients after allogeneic hematopoietic stem cells transplantation - a pilot study

Original language description

Background: Citrulline is an amino acid produced by enterocytes. Serum citrulline concentration has been proposed as a marker of enterocyte mass and function. Our study focused on evaluation of citrulline levels in patients with diarrhea related to toxicintestinal damage (mucositis), intestinal graft versus host disease (GVHD), and other etiology of diarrhea (e. g., dysmicrobia) after allogeneic stem cells transplantation (SCT). Material/Methods: This was a prospective study in 11 adults (18 blood samples) with diarrhea developed after allogeneic SCT in 4/2011-1/2012 compared to twenty healthy control samples. Results: The median (interquartile range) of citrulline levels was significantly lower in the transplanted patients group compared to healthy controls: 9.3 (3.62-15.38) vs. 33.3 (26.82-36.23) mu mol/L, p<0.0001. The median values of citrulline in patients with post-transplant toxic intestinal mucositis (n=8, days 1-22 post-transplant) vs. intestinal GVHD (n=7, day 43-142) vs. ot

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medical Science Monitor [online]

ISSN

1643-3750

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

February

Country of publishing house

FR - FRANCE

Number of pages

5

Pages from-to

81-85

UT code for WoS article

000319920000001

EID of the result in the Scopus database

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