Utility of laboratory testing for the diagnosis of Hymenoptera venom allergy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F16%3A10323936" target="_blank" >RIV/00669806:_____/16:10323936 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/16:10323936
Result on the web
<a href="http://dx.doi.org/10.2500/aap.2016.37.3934" target="_blank" >http://dx.doi.org/10.2500/aap.2016.37.3934</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2500/aap.2016.37.3934" target="_blank" >10.2500/aap.2016.37.3934</a>
Alternative languages
Result language
angličtina
Original language name
Utility of laboratory testing for the diagnosis of Hymenoptera venom allergy
Original language description
Background: A diagnosis of Hymenoptera venom allergy is based on clinical history and the results of skin tests and/or laboratory methods. Objective: To analyze the utility of available laboratory tests in diagnosing Hymenoptera venom allergy. Methods: Ninety-five patients with Hymenoptera venom allergy with a history of bee (35) or wasp (60) anaphylactic sting reaction and positive skin test with bee or wasp venom were included in this analysis. Specific immunoglobulin E (to bee venom extract, wasp venom extract, available recombinant molecules, and a basophil activation test with venom extracts were assessed in all the patients. Test sensitivity and specificity were calculated by using standard threshold values; then, receiver operating characteristic curve analysis was performed to compute optimal threshold values. Also, statistical analysis of the utility of different combinations of laboratory tests was performed. Conclusion: Our analysis confirmed that currently used laboratory tests represent effective tools in diagnosing Hymenoptera venom allergy. Moreover, our probabilistic approach offered another way to interpret concrete values of laboratory test results and opened possible direction on how to optimize the laboratory diagnostic procedure.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Allergy and Asthma Proceedings
ISSN
1088-5412
e-ISSN
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Volume of the periodical
37
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
248-255
UT code for WoS article
000375718500012
EID of the result in the Scopus database
2-s2.0-84968690756