Endometrial endometrioid carcinoma with large cystic growth configuration and deceptive pattern of invasion associated with abundant nodular fasciitis-like stroma: a unique hitherto unreported histology in endometrioid carcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F16%3A10327380" target="_blank" >RIV/00669806:_____/16:10327380 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/16:10327380
Result on the web
<a href="http://dx.doi.org/10.1097/PAP.0000000000000130" target="_blank" >http://dx.doi.org/10.1097/PAP.0000000000000130</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/PAP.0000000000000130" target="_blank" >10.1097/PAP.0000000000000130</a>
Alternative languages
Result language
angličtina
Original language name
Endometrial endometrioid carcinoma with large cystic growth configuration and deceptive pattern of invasion associated with abundant nodular fasciitis-like stroma: a unique hitherto unreported histology in endometrioid carcinoma
Original language description
We describe a case of an unusual endometrial endometrioid carcinoma occurring in a 67-year-old woman. The tumor involved uterine corpus as well as lower uterine segment and presented as polypoid tumor protruding through the cervical orifice. Microscopically, the tumor was characterized by broad zones of cytologically bland fibromyxoid stroma resembling nodular fasciitis, showing vaguely nodular architecture. Neoplastic glands were characterized by interconnected elongated slit-like and large cystic profiles, mostly lined by flattened epithelium with variable squamous differentiation, whereas typical columnar endometrioid cells were only focally present. Voluminous nodules of the stroma produced phyllodes-like appearance of the tumor. The tumor showed some resemblance to the microcystic, elongated, and fragmented (MELF) glands growth pattern, but in contrast with MELF pattern, where fibromyxoid change occurs focally, in the presented case abundant myofibroblastic proliferation was present throughout the tumor and the neoplastic glands showed anastomosing "large cystic" rather than "small cystic" profiles. Some of the neoplastic glands presented almost complete or complete squamous differentiation, with relatively bland-looking squamous cells and no hint of endometrioid differentiation, which resulted in initial misdiagnosis of Mu llerian adenofibroma. We believe that nodular fasciitis-like pattern represents yet undescribed, and diagnostically challenging pattern of invasion in endometrial endometrioid carcinoma.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advances in Anatomic Pathology
ISSN
1072-4109
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
381-384
UT code for WoS article
000386701300004
EID of the result in the Scopus database
2-s2.0-84992200216