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Comparison of autologous hematopoietic cell transplantation performed in tandem and in disease relapse in multiple myeloma patients

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F18%3A10380145" target="_blank" >RIV/00669806:_____/18:10380145 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.elis.sk/download_file.php?product_id=5712&session_id=jh1b5035l8fc5lm7jbsia8kso7" target="_blank" >http://www.elis.sk/download_file.php?product_id=5712&session_id=jh1b5035l8fc5lm7jbsia8kso7</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.4149/neo_2018_170511N346" target="_blank" >10.4149/neo_2018_170511N346</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Comparison of autologous hematopoietic cell transplantation performed in tandem and in disease relapse in multiple myeloma patients

  • Original language description

    Multiple myeloma is a malignant hemato-oncological malignancy that affects up to 600 people in the Czech Republic every year. Treatment options are under constant improvement and the autologous hematopoietic cell transplantation (Tx) remains a part of treatment protocols. Despite modern drug administration, the autologous Tx keeps its irreplaceable position and when ensuring two autologous Tx, the studies confirm a survival time that is more than twice as long as in nontransplant patients. However, there are no standardized procedures specifying the period in between the transplantations in more details. Within our group, we compared the total of 66 patients who were administered a double transplant. One group underwent both planned tandem autologous Tx within a median of six months while mostly reaching just a partial remission (PR) and less after the first transplant and out of disease progression. The other group of patients only underwent the second Tx within a median of up to 14 months during a progression period or disease relapse. Both groups were comparable as far as basic parameters are concerned (age, type of induction therapy, cytogenetic risk). A significantly better TFS (treatment free survival) and overall survival (OS) were observed in the group where a tandem Tx was administered. TFS was 18 months and median OS was not reached for the group of patients who received tandem Tx while TFS was 10 months (p=0.04) and median OS was 57 months (p=0.005) for those who received delayed second Tx. In the group of patients who received second Tx during relapse, we observed that TFS and OS were shorter in those with a higher paraprotein level, suggesting the potential role of paraprotein level as a prognostic marker. The TFS in the subgroup with a high initial level was 4 months vs. 11 months (p=0.0016) and OS 44 months vs. 65 months (p=0.03).

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30205 - Hematology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Neoplasma

  • ISSN

    0028-2685

  • e-ISSN

  • Volume of the periodical

    65

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    SK - SLOVAKIA

  • Number of pages

    6

  • Pages from-to

    952-957

  • UT code for WoS article

    000455707400001

  • EID of the result in the Scopus database

    2-s2.0-85057289152