Viral load and duration of BK polyomavirus viremia determine renal graft fibrosis progression: histologic evaluation of late protocol biopsies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F19%3A10400750" target="_blank" >RIV/00669806:_____/19:10400750 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/19:10400750
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=G3nO-xq_LN" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=G3nO-xq_LN</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/ndt/gfz061" target="_blank" >10.1093/ndt/gfz061</a>
Alternative languages
Result language
angličtina
Original language name
Viral load and duration of BK polyomavirus viremia determine renal graft fibrosis progression: histologic evaluation of late protocol biopsies
Original language description
Background. Polyomavirus BK (BKV) infection of the renal allograft causes destructive tissue injury with inflammation and subsequent fibrosis. Methods. Using a prospective cohort of patients after kidney transplantation performed between 2003 and 2012 we investigated the role of BKV viremia in the development and progression of interstitial fibrosis and tubular atrophy (IFTA). Primary outcome was moderate-to-severe IFTA assessed by protocol biopsy at 36 months. Results. A total of 207 consecutive recipients were enrolled. Of these, 57 (28%) developed BKV viremia with 10 (5%) cases of polyomavirus-associated nephropathy. Transient (<3 months) BKV viremia occurred in 70% patients while persistent (>=3 months) BKV viremia in 30%. A high viral load (>=10,000 copies/mL) was detected in 18%, a low viral load (<10,000 copies/mL) in 61%; while the viral load could not be determined in 21%. Moderate-to-severe IFTA was significantly increased in high (71%; odds ratio, 12.1; 95% confidence interval, 1.62-90.0; P=0.015) or persistent BKV viremia (67%; odds ratio, 6.33; 95% confidence interval, 1.19-33.7; P=0.031) with corresponding rise in "interstitial fibrosis + tubular atrophy" scores. Only patients with transient low BKV viremia showed similar incidence and progression of IFTA as no-BKV group. Persistent low BKV viremia was uncommon yet the progression of fibrosis was significant. Only recipients with polyomavirus-associated nephropathy experienced inferior graft survival at 5 years. Conclusions. These data suggest only transient low BKV viremia does not negatively affect the progression of allograft fibrosis in contrast to excessive risk of severe fibrosis after high or persistent BKV viremia.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology
Result continuities
Project
<a href="/en/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nephrology, Dialysis, Transplantation
ISSN
0931-0509
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
1970-1978
UT code for WoS article
000498168100023
EID of the result in the Scopus database
2-s2.0-85073979583