Blunt injury of liver - mechanical response of porcine liver in experimental impact test
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F21%3A10422774" target="_blank" >RIV/00669806:_____/21:10422774 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/21:10422774 RIV/49777513:23520/21:43961014 RIV/49777513:23640/21:43961014
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NtQVQ~fhuo" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NtQVQ~fhuo</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1088/1361-6579/abdf3c" target="_blank" >10.1088/1361-6579/abdf3c</a>
Alternative languages
Result language
angličtina
Original language name
Blunt injury of liver - mechanical response of porcine liver in experimental impact test
Original language description
Liver is frequently injured in blunt abdominal trauma caused by road traffic accidents. The testing of safety performance of vehicles, e.g. belt usage, head support, seat shape, or air bag shape, material, pressure, and reaction, could lead to reduction of the injury seriousness. Current trends in safety testing include development of accurate computational human body models (HBM's) based on the anatomical, morphological, and mechanical behavior of tissues under high strain. The aim of this study was to describe the internal pressure changes within porcine liver, the severity of liver injury and the relation between the porcine liver microstructure and rupture propagation in an experimental impact test. Porcine liver specimens (n = 24) were uniformly compressed using a drop tower technique and four impact heights (200, 300, 400 and 500 mm; corresponding velocities: 1.72, 2.17, 2.54, and 2.88 m/s). The changes in intravascular pressure were measured via catheters placed in portal vein and caudate vena cava. The induced injuries were analyzed on macroscopic level according to AAST grade and AIS severity. Rupture propagation with respect to liver microstructure was analyzed using stereological methods. Macroscopic ruptures affected mostly the interface between connective tissue surrounding big vessels and liver parenchyma. Histological analysis revealed that the ruptures avoided reticular fibers and interlobular septa made of connective tissue on the microscopic level. The present findings can be used for evaluation of HBM's of liver behavior in impact situations.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30106 - Anatomy and morphology (plant science to be 1.6)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Measurement
ISSN
0967-3334
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
025008
UT code for WoS article
000627725600001
EID of the result in the Scopus database
2-s2.0-85102964002