Low serum vitamin D levels are associated with a low percentage of TREM-2(+) monocytes in low-grade gliomas and poorer overall survival in patients with high-grade gliomas

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F21%3A10427570" target="_blank" >RIV/00669806:_____/21:10427570 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/21:10427570

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=VFRM~JqAbF" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=VFRM~JqAbF</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2021_027" target="_blank" >10.4149/BLL_2021_027</a>

Result language

angličtina

Original language name

Low serum vitamin D levels are associated with a low percentage of TREM-2(+) monocytes in low-grade gliomas and poorer overall survival in patients with high-grade gliomas

Original language description

INTRODUCTION: Anti-inflammatory effect of vitamin D (VD) could be beneficial in improving the survival of glioma patients. The aim of our study was to analyse the serum levels of vitamin D in glioma patients and to find an association with the prognosis of glioma patients and other investigated parameters. MATERIAL AND METHODS: The study included 63 patients with gliomas. Percentage of CD14(+) monocytes, TREM-1(+) and TREM-2(+) monocytes were determined by flow cytometry, serum levels of 25(OH)D were evaluated by electrochemiluminescent binding test. RESULTS: Six patients out of 63 had normal levels of VD. A significant difference in the overall survival (OS) in the patients with severe VD deficiency, VD deficiency and insufficiency in grade IV was found. In grade II and III, the levels of vitamin D positively correlated with the percentage of TREM-2(+) monocytes, and in grade II also a negative correlation of VD with TREM-1/TREM-2 ratio was observed. CONCLUSION: Levels of VD could influence the prognosis of patients with high-grade gliomas. Serum level of 25(OH)D in low-grade gliomas positively correlated with the percentage of anti-inflammatory acting TREM-2(+) monocytes and negatively with TREM-1/TREM-2 ratio. This could be protective against the progression to high-grade glioma, because TREM-2 is associated with protective functions such as: tissue repair, control of local inflammation, or phagocytosis (Tab. 4, Fig. 4, Ref. 79).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30109 - Pathology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bratislavské lekárske listy / Bratislava Medical Journal

ISSN

0006-9248

e-ISSN

—

Volume of the periodical

122

Issue of the periodical within the volume

3

Country of publishing house

SK - SLOVAKIA

Number of pages

7

Pages from-to

172-178

UT code for WoS article

000637613200002

EID of the result in the Scopus database

2-s2.0-85101946351