Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F22%3A10440120" target="_blank" >RIV/00669806:_____/22:10440120 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/22:00076110 RIV/00098892:_____/22:10157317 RIV/61989592:15110/22:73614772 RIV/00179906:_____/22:10440120 RIV/61988987:17110/22:A2302FJP
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=tKp6cWS8Ds" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=tKp6cWS8Ds</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1182/bloodadvances.2020003876" target="_blank" >10.1182/bloodadvances.2020003876</a>
Alternative languages
Result language
angličtina
Original language name
Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine
Original language description
Multiple myeloma (MM) measurable residual disease (MRD) persisting after treatment is an adverse prognostic factor for progression-free survival (PFS) and overall survival. Genomic mutations occurring in the remaining clonal aberrant plasma cells (A-PCs) are linked to the development of drug resistance and disease relapse. Thus, personalized treatment based on the genomic profile of MRD could be highly beneficial and ultimately increase patients' survival. However, although large-scale sequencing studies have characterized the genome of many malignancies, including MM, the genomic mutations present in MM MRD exist at the beginning of investigation. Here, we set up an exome sequencing analysis to identify genomic mutations characteristic for MM MRD and explore if they could mediate drug response, resistance, or disease progression.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Blood Advances
ISSN
2473-9529
e-ISSN
2473-9537
Volume of the periodical
6
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
368-372
UT code for WoS article
000753857400002
EID of the result in the Scopus database
2-s2.0-85123507705