TSC/mTOR pathway mutation associated eosinophilic/oncocytic renal neoplasmsm: a heterogeneous group of tumors with distinct morhpology, immunohistochemical profile, and similar genetic background
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F22%3A10443633" target="_blank" >RIV/00669806:_____/22:10443633 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/22:10443633
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3hFtgIs.mM" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3hFtgIs.mM</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biomedicines10020322" target="_blank" >10.3390/biomedicines10020322</a>
Alternative languages
Result language
angličtina
Original language name
TSC/mTOR pathway mutation associated eosinophilic/oncocytic renal neoplasmsm: a heterogeneous group of tumors with distinct morhpology, immunohistochemical profile, and similar genetic background
Original language description
A number of recently described renal tumor entities share an eosinophilic/oncocytic morphology, somewhat solid architectural growth pattern, and tendency to present as low-stage tumors. The vast majority of such tumors follow a non-aggressive clinical behavior. In this review, we discuss the morphological, immunohistochemical, and molecular genetic profiles of the three most recent novel/emerging renal entities associated with TSC/mTOR pathway mutations. These are eosinophilic solid and cystic renal cell carcinoma, eosinophilic vacuolated tumors, and lowgrade oncocytic tumors, which belong to a heterogeneous group of renal tumors, demonstrating mostly solid architecture, eosinophilic/oncocytic cytoplasm, and overlapping morphological and immunohistochemical features between renal oncocytoma and chromophobe renal cell carcinoma. All three tumors also share a molecular genetic background with mutations in the mTORC1 pathway (TSC1/TSC2/mTOR/RHEB). Despite the common genetic background, it appears that the tumors with TSC/mTOR mutations represent a diverse group of distinct renal neoplasms.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedicines [online]
ISSN
2227-9059
e-ISSN
2227-9059
Volume of the periodical
10
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
322
UT code for WoS article
000764282400001
EID of the result in the Scopus database
2-s2.0-85124093874