Transient Hyperphosphatasemia in a Child with Autism Spectrum Disorder

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F22%3A10445726" target="_blank" >RIV/00669806:_____/22:10445726 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/22:10445726 RIV/00216208:11110/22:10445726 RIV/00216208:11140/22:10445726

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=GuBeTNcLyV" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=GuBeTNcLyV</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/18059694.2022.16" target="_blank" >10.14712/18059694.2022.16</a>

Result language

angličtina

Original language name

Transient Hyperphosphatasemia in a Child with Autism Spectrum Disorder

Original language description

Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and the presence of restricted interests and repetitive behaviors. Transient hyperphosphatasemia of infancy and early childhood (THI) is a benign laboratory disorder characterized by transiently extremely elevated activity of serum alkaline phosphatase (S-ALP). Case Report: We present a 21-month-old girl with a right leg limp, most probably due to reactive arthritis after febrile viral infection, and deterioration of psychomotor development with concomitant transient elevation of S-ALP. Normal values of serum creatinine, aspartate-aminotransferase, alanin-aminotransferase, calcium, phosphate, together with normal wrist X-ray ruled out rickets or other bone or hepatic cause of high S-ALP. The S-ALP gradually decreased within 3 months, thus fulfilling the THI criteria. Screening for inborn errors of metabolism was negative and meticulous neurologic, psychologic ans psychiatric assessment pointed to the diagnosis of autism spectrum disorder (ASD). There was no causal relationship between THI and ASD, as high S-ALP was an accidental and transient finging within the routine laboratory assessment. However, when THI occurs in a child with an onset of a new disorder, or with a pre-existing bone of liver disease, it might seriously concern the physician. Conclusion: Children with THI should be spared from extensive evaluations and unnecessary blood draws.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30209 - Paediatrics

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Medica (Hradec Králové)

ISSN

1211-4286

e-ISSN

1805-9694

Volume of the periodical

65

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

3

Pages from-to

41-43

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85133563610