Unexpected Heterogeneity of Newly Diagnosed Multiple Myeloma Patients with Plasmacytomas

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F22%3A10448822" target="_blank" >RIV/00669806:_____/22:10448822 - isvavai.cz</a>
Alternative codes found
RIV/00843989:_____/22:E0109845 RIV/65269705:_____/22:00076456 RIV/00064173:_____/22:43924109 RIV/00098892:_____/22:10157300 and 7 more
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=03C.N5eihU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=03C.N5eihU</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biomedicines10102535" target="_blank" >10.3390/biomedicines10102535</a>

Result language
angličtina
Original language name
Unexpected Heterogeneity of Newly Diagnosed Multiple Myeloma Patients with Plasmacytomas
Original language description
In multiple myeloma (MM), malignant plasma cells infiltrate the bone marrow. In some cases, plasma cells migrate out of the bone marrow creating either para-skeletal plasmacytomas (PS) or infiltrating soft tissues as extramedullary plasmacytomas (EMD). The aim of this study was to define risk groups in newly diagnosed MM (NDMM) patients with PS and EMD plasmacytomas. In total, 523 NDMM patients with PS plasmacytomas and 196 NDMM patients with EMD plasmacytomas were diagnosed in the Czech Republic between 2004 and 2021 using modern imaging methods. Patients' data were analyzed from the Registry of Monoclonal Gammopathies of the Czech Myeloma Group. In NDMM patients with PS plasmacytomas, we found a subgroup with <5% of bonemarrow plasma cells to have the best prognosis (mPFS: 58.3 months (95% CI: 33.0-NA); mOS: not reached). The subgroup with >5% of bone-marrow plasma cells and >=3 plasmacytomas had the worst prognosis (mPFS: 19.3 months (95% CI: 13.4-28.8), p < 0.001; mOS: 27.9 months (95% CI: 19.3-67.8), p < 0.001). Our results show association between tumor burden and prognosis of NDMM patients with plasmacytomas. In the case of PS plasmacytomas, NDMM patients with low BM PC infiltration have an excellent prognosis.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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