Bronchial Asthma as a Cardiovascular Risk Factor: A Prospective Observational Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F22%3A10449437" target="_blank" >RIV/00669806:_____/22:10449437 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/22:10449437
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=S4B1FEyjeM" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=S4B1FEyjeM</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biomedicines10102614" target="_blank" >10.3390/biomedicines10102614</a>
Alternative languages
Result language
angličtina
Original language name
Bronchial Asthma as a Cardiovascular Risk Factor: A Prospective Observational Study
Original language description
Introduction: Asthma as a chronic inflammatory disorder has been suggested as a risk factor for endothelial dysfunction (ED), but studies on the association between asthma and cardiovascular disease (CVD) risk are limited. Background: We assessed associations of ED with the severity of asthma, eosinophilic inflammation, lung function, and asthma control. Methods: 52 young asthmatics (median age of 25.22 years) and 45 healthy individuals were included. Demographic, clinical , and laboratory findings were recorded. We evaluated microvascular responsiveness by recording the reactive hyperemia index (RHI) indicating post-occlusive peripheral endothelium -dependent changes in vascular tone using the Itamar Medical EndoPAT2000, VCAM-1, ADMA, high-sensitive CRP(hsCRP), and E-selectin werte measured. Results: Asthmatics had considerably lower RHI values (p<0.001) with a dynamic decreasing trend by asthma severity and higher hsCRP levels (p<0.001). A substantial increase in hsCRP and E-selectin with asthma severity (p<0.05) was also observed. We confirmed a higher body mass index (BMI) in asthmatics (p<0.001), especially in women and in severe asthma. Conclusions: We demonstrated the progression of CVD in asthmatics and the association of the ongoing deterioration of ED with the inflammatory severity, suggesting that the increased risk of CVD in young asthmatics is dependent on disease severity. The underlying mechanism of risk factors for CVD and disease control require further study.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedicines [online]
ISSN
2227-9059
e-ISSN
2227-9059
Volume of the periodical
10
Issue of the periodical within the volume
10
Country of publishing house
CH - SWITZERLAND
Number of pages
17
Pages from-to
2614
UT code for WoS article
000872407400001
EID of the result in the Scopus database
2-s2.0-85140630011