Risk of genitourinary malignancy in patients that receive anticoagulant or antiplatelet therapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F23%3A10469471" target="_blank" >RIV/00669806:_____/23:10469471 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/23:A2402N2N RIV/00216208:11120/23:43926147 RIV/00216208:11140/23:10469471 RIV/61989100:27240/23:10254174 and 2 more

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=R_uZzMbh-u" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=R_uZzMbh-u</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2023_112" target="_blank" >10.4149/BLL_2023_112</a>

Result language

angličtina

Original language name

Risk of genitourinary malignancy in patients that receive anticoagulant or antiplatelet therapy

Original language description

OBJECTIVES: Haematuria is a common indication for a urology evaluation. In many cases, its cause is not determined unequivocally, but it does not pose any threat to the patient. However, it can represent the fi rst symptom of urinary tract cancer. BACKGROUND: The present study aimed to compare the risk of urological malignancies in patients with haematuria who received antiplatelet or anticoagulant therapy versus those who did not. METHODS: This prospective study included 562 patients with haematuria during the period of 2018-2021. Among these, 129 patients had macroscopic haematuria. All patients underwent a urinary tract ultrasound, CT with urography, and cystoscopy. Patients with suspected malignancy underwent an appropriate surgical procedure with a pathology examination. Data were analysed with univariate and multiple logistic regression. RESULTS: The incidence rates of malignancies were 21.5 % overall, and 44.2 % and 14.8 % among patients with macroscopic and microscopic haematuria, respectively. Univariate regression showed that the odds of malignancy was signifi cantly higher among patients with antiplatelet therapy compared to patients without antiplatelet therapy (OR: 1.88, 95% CI: 1.14-3.05). In contrast, anticoagulation therapy did not signifi cantly increase the odds of malignancy compared to no anticoagulation therapy (OR: 1.45, 95% CI: 0.74-2.69). However, a multiple logistic regression model that included other known risk factors (e.g., sex or age) showed similar odds of malignancy among these patient groups. CONCLUSIONS: Malignancy risk for patients who received anticoagulant or antiplatelet therapy was similar to the risk observed in the general population. Antiplatelet and anticoagulant therapy were not signifi cant risk factors of urological malignancy in patients with haematuria. The results from the present study will be used in a power analysis for an upcoming multicentre study

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30217 - Urology and nephrology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bratislavské lekárske listy / Bratislava Medical Journal

ISSN

0006-9248

e-ISSN

1336-0345

Volume of the periodical

124

Issue of the periodical within the volume

10

Country of publishing house

SK - SLOVAKIA

Number of pages

4

Pages from-to

738-741

UT code for WoS article

001085010500003

EID of the result in the Scopus database

2-s2.0-85172393794