Impact of autoimmune gastritis on chronic urticaria in paediatric patients - pathophysiological point of views
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F24%3A10470922" target="_blank" >RIV/00669806:_____/24:10470922 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/24:10470922
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=b7kLHdso~K" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=b7kLHdso~K</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00431-023-05324-2" target="_blank" >10.1007/s00431-023-05324-2</a>
Alternative languages
Result language
angličtina
Original language name
Impact of autoimmune gastritis on chronic urticaria in paediatric patients - pathophysiological point of views
Original language description
We would like to provide an updated comprehensive perspective and identify the components linked to chronic spontaneous urticaria (CSU) without specific triggers in autoimmune atrophic gastritis (AAG). AAG is an organ-specific autoimmune disease that affects the corpus-fundus gastric mucosa. Although we lack a unified explanation of the underlying pathways, when considering all paediatric patients reported in the literature, alterations reslult in gastric neuroendocrine enterochrmaffin-like (ECL) cell proliferation and paracrine release of histamine. Several mechanism have been proposed for the pathogenesis of CSU, with much evidence pointing towards AAG and ECL cell responses, which may be implicated as potential factors contributing to CSU. The excessive production/release of histamine into the bloodstream could cause or trigger exacerbations of CSU in AAG, independent of Helicobacter pylori; thus, the release of histamine from ECL cells may be the primary modulator. Conclusion: Considering the understanding of these interactions, recognising the respective roles of AAG in the pathogenesis of CSU may strongly impactt the diagnostic workup and management of unexplained/refractory CSU and may inform future research and interventions in the paediatric population.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30209 - Paediatrics
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Pediatrics
ISSN
0340-6199
e-ISSN
1432-1076
Volume of the periodical
183
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
515-522
UT code for WoS article
001100533400001
EID of the result in the Scopus database
2-s2.0-85176545925