Identifying Leukopenia, Renal Dysfunction and Other Factors Limiting Concomitant Chemoradiotherapy in Locally Advanced Cervical Cancer: A Way to Focus on the Importance of Supportive Care and Potentially Improve Treatment Results?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F25%3A10503154" target="_blank" >RIV/00669806:_____/25:10503154 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/25:10503154

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=n.k13m6iio" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=n.k13m6iio</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7759/cureus.90633" target="_blank" >10.7759/cureus.90633</a>

Result language

angličtina

Original language name

Identifying Leukopenia, Renal Dysfunction and Other Factors Limiting Concomitant Chemoradiotherapy in Locally Advanced Cervical Cancer: A Way to Focus on the Importance of Supportive Care and Potentially Improve Treatment Results?

Original language description

INTRODUCTION: Concomitant chemoradiotherapy (CHRT) with weekly cisplatin and image-guided adaptive brachytherapy (IGABT) is the standard treatment for unresectable locally advanced cervical cancer. It has been shown that receiving five or more cycles of concomitant chemotherapy (CHT) significantly improves recurrence-free and overall survival. In this study, we analysed the factors contributing to the omission of concomitant chemotherapy within a patient cohort. METHODS: In this single-centre retrospective study, we analysed medical records of 191 patients treated at our facility (Department of Oncology and Radiotherapeutics, University Hospital Pilsen, Czech Republic) from 2012 to 2024 to identify factors preventing optimal CHT administration. Included patients were those with newly diagnosed locally advanced, unresectable cervical cancer, where concomitant platinum-based CHRT with IGABT was indicated. RESULTS: Of the patients, 15% (29/191) received no concomitant CHT, primarily due to concerns about toxicity, patient frailty/comorbidities, and renal insufficiency, with a statistically significant age difference in those who received CHT versus those who did not: mean 55.03 (±SD11.89) vs. 63.52 (±SD12.14) years (95% CI 3.74-13.23, p=0.0005). Among patients who initiated concomitant CHT but received four or fewer cycles (92/162, 57%), leukopenia was the most common independent limiting factor, followed by decreased renal function. Other factors included nausea, diarrhea, and administrative reasons. CONCLUSION: Leukopenia and renal dysfunction were primary barriers to completing optimal concomitant CHT in a significant number of patients. We advocate for increased emphasis on supportive care, including granulocyte colony-stimulating factor (G-CSF) use in leukopenia/neutropenia prevention or treatment, and meticulous management of renal functions. Individualized renal assessment, not just &apos;cisplatin-unfit&apos; criteria, is crucial. Further research on G-CSFs in CHRT is warranted.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30204 - Oncology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Curēus

ISSN

2168-8184

e-ISSN

2168-8184

Volume of the periodical

17

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

e90633

UT code for WoS article

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EID of the result in the Scopus database

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