Safety and efficacy of the sonographic acceleration of the middle cerebral artery recanalization: results of the pilot thrombotripsy study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F08%3A00016033" target="_blank" >RIV/00843989:_____/08:00016033 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Safety and efficacy of the sonographic acceleration of the middle cerebral artery recanalization: results of the pilot thrombotripsy study
Original language description
The aim was to demonstrate the safety and efficacy of continuous ultrasound monitoring of the artery occlusion area (sonothrombotripsy) in patients with acute middle cerebral artery (MCA) occlusion. A total of 52 consecutive patients with acute MCA occlusion were included in the thrombotripsy group. Doppler monitoring of the region of occlusion was performed for up to 45 minutes. The control group was created from the NAIS study database. In the Thrombotripsy group, 19 patients (36.5%) had complete recanalization and 27 (51.9%) patients had partial recanalization at one hour after the start of the TCCS monitoring. Higher recanalization rates at 6 and 24 hours after stoke onset were also seen compared to controls (69.2% vs. 7.7% and 92.3% vs. 61.5% complete recanalizations resp., p < 0.05). Independence (mRS 0-2) at day 90 was achieved by 61.5% of the Thrombotripsy patients and 32.7% controls, p < 0.05, OR 1.88 (95% CI = 1.23 ? 2.90).
Czech name
Bezpečnost a účinnost akcelerace rekanalizace střední mozkové tepny pomocí ultrazvuku: výsledky pilotní Thrombotripsy study
Czech description
Cílem studie bylo prokázat bezpečnost a účinnost kontinuálního ultrazvukového monitoringu okludované tepny (sonotrombotripse) u pacientů s akutní okluzí a. cerebri media (ACM). Do studie bylo zařazeno 52 pacientů s okluzí ACM (skupina 1), u nichž byl proveden Dopplerovský monitoring oblasti tepenné okluze po dobu maximálně 45 minut. Kontrolní skupina (skupina 2) byla vybrána ze studie NAIS. Ve skupině 1 došlo k plné rekanalizaci tepny do 60 minut u 19 pacientů (36,5%) a u 27 (51.9%) pacientů byla rekanalizace parciální. Vyšší procento kompletních rekanalizací 6 a 24 hodin od začátku symptomů bylo ve skupině 1 ve srovnání se skuponou 2 (69,2% vs. 7,7% and 92,3% vs. 61,5%, p < 0.05). Nezávislost (mRS 0-2) po 90 dnech bylo dosaženo u 61,5% pacientů ve skupině 1 a 32,7% kontrol, p < 0.05, OR 1.88 (95% CI = 1.23 ? 2.90).
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Ultrasound in Medicine & Biology
ISSN
0301-5629
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
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UT code for WoS article
000260611000010
EID of the result in the Scopus database
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