Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F10%3A00101513" target="_blank" >RIV/00843989:_____/10:00101513 - isvavai.cz</a>

Alternative codes found

RIV/61989100:27510/10:86075094

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer

Original language description

Fifty percent of diabetics (7% of general population) suffer from peripheral arterial occlusive disease, which may lead to amputation due to critical limb ischemia (CLI). The aim of our study was to prevent major limb amputation (MLA) in this group of patients using a local application of autologous bone marrow stem cells (ABMSC) concentrate. A total of 96 patients with CLI and foot ulcer (FU) were randomized into groups I and II. Patients in group I (n = 42, 36 males, 6 females, 66.2 +/- 10.6 years) underwent local treatment with ABMSC while those in group II (n = 54, control, 42 males, 12 females, 64.1 +/- 8.6 years) received standard medical care. The frequency of major limb amputation in groups I and II was 21% and 44% within the 120 days of followup, respectively (p < 0.05). Only in salvaged limbs of group I both toe pressure and toe brachial index increased (from 22.66 +/- 5.32 to 25.63 +/- 4.75 mmHg and from 0.14 +/- 0.03 to 0.17 +/- 0.03, respectively, mean +/- SEM). The CD34(

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

—

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell transplantation

ISSN

0963-6897

e-ISSN

—

Volume of the periodical

19

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

—

UT code for WoS article

000286084900005

EID of the result in the Scopus database

—