Double-blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's disease.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F10%3A00103123" target="_blank" >RIV/00843989:_____/10:00103123 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/mds.22948" target="_blank" >http://dx.doi.org/10.1002/mds.22948</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mds.22948" target="_blank" >10.1002/mds.22948</a>

Result language

angličtina

Original language name

Double-blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's disease.

Original language description

This study examined the efficacy and safety of the partial dopamine agonist, pardoprunox (SLV308), in the treatment of patients with early Parkinson's disease (PD). Patients were randomized to receive pardoprunox (n = 69) or placebo (n = 70). Pardoprunoxwas titrated to each patient's optimal dose (9-45 mg/d) over 2 to 6 weeks and then maintained at this dose for a further 3 weeks. Concomitant anti-Parkinson treatment was not permitted. In the primary analysis, Unified PD Rating Scale (UPDRS)-Motor score was improved in pardoprunox-treated patients (overall mean dose 23.8 mg/d; -7.3 points), as compared with placebo (-3.0 points; P = 0.0001), from baseline to end point. At end point, there were more responders (>= 30% reduction in UPDRS-Motor score) inthe pardoprunox group (50.7%) than in the placebo group (15.7%; P < 0.0001). In other secondary analyses, UPDRS-activities of daily living (ADL) and -ADL+Motor scores were also significantly more improved in the pardoprunox group. Nausea

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Movement disorders

ISSN

0885-3185

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

738-746

UT code for WoS article

000277311500011

EID of the result in the Scopus database

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