Motavizumab for prophylaxis of respiratory syncytial virus in high-risk children: a noninferiority trial
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F10%3A00103135" target="_blank" >RIV/00843989:_____/10:00103135 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1542/peds.2008-1036" target="_blank" >http://dx.doi.org/10.1542/peds.2008-1036</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1542/peds.2008-1036" target="_blank" >10.1542/peds.2008-1036</a>
Alternative languages
Result language
angličtina
Original language name
Motavizumab for prophylaxis of respiratory syncytial virus in high-risk children: a noninferiority trial
Original language description
OBJECTIVE: Palivizumab reduces respiratory syncytial virus (RSV) hospitalization in children at high risk by similar to 50% compared with placebo. We compared the efficacy and safety of motavizumab, an investigational monoclonal antibody with enhanced anti-RSV activity in preclinical studies, with palivizumab. METHODS: This randomized, double-blind, multinational, phase 3, noninferiority trial assessed safety and RSV hospitalization in 6635 preterm infants aged <= 6 months at enrollment or children aged<= 24 months with chronic lung disease of prematurity who received 15 mg/kg palivizumab or motavizumab monthly. Secondary end points included outpatient medically attended lower respiratory tract infections (MALRIs), RSV-specific LRIs, otitis media, antibiotic use, development of antimotavizumab antibodies, and motavizumab serum concentrations. RESULTS: Motavizumab recipients had a 26% relative reduction in RSV hospitalization compared with palivizumab recipients, achieving noninferiori
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FG - Paediatrics
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pediatrics
ISSN
0031-4005
e-ISSN
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Volume of the periodical
125
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
"e35"-"e51"
UT code for WoS article
000273348000034
EID of the result in the Scopus database
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