Comparable renal function at 6 months with tacrolimus combined with fixed-dose sirolimus or MMF: Results of a randomized multicenter trial in renal transplantation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F10%3A00103156" target="_blank" >RIV/00843989:_____/10:00103156 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1155/2010/731426" target="_blank" >http://dx.doi.org/10.1155/2010/731426</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2010/731426" target="_blank" >10.1155/2010/731426</a>

Result language

angličtina

Original language name

Comparable renal function at 6 months with tacrolimus combined with fixed-dose sirolimus or MMF: Results of a randomized multicenter trial in renal transplantation

Original language description

In a multicenter trial, renal transplant recipients were randomized to tacrolimus with fixed-dose sirolimus (Tac/SRL, N = 318) or tacrolimus with MMF (Tac/MMF, N = 316). Targeted tacrolimus trough levels were lower in the Tac/SRL group after day 14. Theprimary endpoint was renal function at 6 months using creatinine clearance (Cockcroft-Gault) and was comparable at 66.4?mL/min (SE 1.4) with Tac/SRL and at 65.2mL/min (SE 1.3) with Tac/MMF (completers). Biopsy-confirmed acute rejection was 15.1% (Tac/SRL) and 12.3% (Tac/MMF). In both groups, graft survival was 93% and patient survival was 99.0%. Premature withdrawal due to an adverse event was twice as high in the Tac/SRL group, 15.1% versus 6.3%. Hypercholesterolemia incidence was higher with Tac/SRL (P < .05) while CMV, leukopenia, and diarrhea incidences were higher with Tac/MMF (P < .05). The incidence of any antidiabetic treatment for >30 consecutive days in previously nondiabetic patients was 17.8%, Tac/SRL, and 24.8%, Tac/MMF. Ev

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of transplantation

ISSN

2090-0007

e-ISSN

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Volume of the periodical

2010

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

1-10

UT code for WoS article

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EID of the result in the Scopus database

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