Intravesical instillation of botulinum toxin A: an in vivo murine study and pilot clinical trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F11%3A00102059" target="_blank" >RIV/00843989:_____/11:00102059 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s11255-010-9790-z" target="_blank" >http://dx.doi.org/10.1007/s11255-010-9790-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11255-010-9790-z" target="_blank" >10.1007/s11255-010-9790-z</a>

Result language

angličtina

Original language name

Intravesical instillation of botulinum toxin A: an in vivo murine study and pilot clinical trial

Original language description

The objectives of this study were to compare the urodynamic effects of botulinum toxin A (BoNT-A) delivered via intramural injection into the bladder wall to that of intravesical instillation in a rat model of detrusor overactivity and to evaluate the effects of intravesical instillation of BoNT-A in female patients with idiopathic overactive bladder. Detrusor overactivity was induced in female Wistar rats using partial bladder outflow obstruction. Animals were treated with 5 units (U) of BoNT-A via intramural bladder injection (n = 6) or intravesical instillation (n = 7). Conscious cystometrograms were performed prior to BoNT-A administration and then repeated 7 days and 2 weeks following treatment. In the subsequent pilot clinical study, 16 female patients with overactive bladder refractory to antimuscarinics were treated with 200 units of BoNT-A in 50 mL of 0.9% saline instilled using a 12-F urethral catheter. Treatment outcome was evaluated immediately prior to and 1 month after Bo

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International urology and nephrology

ISSN

0301-1623

e-ISSN

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Volume of the periodical

43

Issue of the periodical within the volume

2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

7

Pages from-to

337-343

UT code for WoS article

000290573600009

EID of the result in the Scopus database

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