Addition of spironolactone in patients with resistent arterial hypertension (ASPIRANT): a randomized, double-blind, placebo-controlled trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F11%3A00102104" target="_blank" >RIV/00843989:_____/11:00102104 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.169961" target="_blank" >http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.169961</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.169961" target="_blank" >10.1161/HYPERTENSIONAHA.111.169961</a>

Result language

angličtina

Original language name

Addition of spironolactone in patients with resistent arterial hypertension (ASPIRANT): a randomized, double-blind, placebo-controlled trial

Original language description

There is currently limited data on which drug should be used to improve blood pressure (BP) control in patients with resistant hypertension. This study was designed to assess the effect of the addition of 25 mg of spironolactone on BP in patients with resistant arterial hypertension. Patients with office systolic BP > 140 mm Hg or diastolic BP > 90 mm Hg despite treatment with at least 3 antihypertensive drugs, including a diuretic, were enrolled in this double-blind, placebo-controlled, multicenter trial. One hundred seventeen patients were randomly assigned to receive spironolactone (n = 59) or a placebo (n = 58) as an add-on to their antihypertensive medication, by the method of simple randomization. Analyses were done with 111 patients (55 in the spironolactone and 56 in the placebo groups). At 8 weeks, the primary end points, a difference in mean fall of BP on daytime ambulatory BP monitoring (ABPM), between the groups was -5.4 mm Hg (95% CI -10.0; -0.8) for systolic BP (P = 0.024

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Hypertension

ISSN

0194-911X

e-ISSN

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Volume of the periodical

57

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

1069-1075

UT code for WoS article

000290710800017

EID of the result in the Scopus database

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