Interferon ?-1b-neutralizing antibodies 5 years after clinically isolated syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F11%3A00103098" target="_blank" >RIV/00843989:_____/11:00103098 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1212/WNL.0b013e31822c90d7" target="_blank" >http://dx.doi.org/10.1212/WNL.0b013e31822c90d7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1212/WNL.0b013e31822c90d7" target="_blank" >10.1212/WNL.0b013e31822c90d7</a>
Alternative languages
Result language
angličtina
Original language name
Interferon ?-1b-neutralizing antibodies 5 years after clinically isolated syndrome
Original language description
Objective: To determine the frequency and consequences of neutralizing antibodies (NAbs) in patients with a first event suggestive of multiple sclerosis (MS) treated with interferon beta-1b (IFN beta-1b). Methods: In the Betaseron/Betaferon in Newly Emerging MS For Initial Treatment (BENEFIT) study, patients were randomly assigned to 250 mu g IFN beta-1b (Betaferon) or placebo subcutaneously every other day for 2 years or until diagnosis of clinically definite MS (CDMS). Patients were then offered open-label IFN beta-1b for up to 5 years. NAb status was assessed every 6 months by the myxovirus protein A induction assay. A titer >20 NU/mL was considered NAb-positive, with low (>= 20-100 NU/mL), medium (>= 100-400 NU/mL), and high (>= 400 NU/mL) titer categories. Here we examine early-treated patients, who received IFN beta-1b for up to 5 years. Results: NAbs were measured in 277 of 292 early-treated patients and detected at least once in 88 (31.8%) patients, with 53 (60.2%) reverting to
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neurology
ISSN
0028-3878
e-ISSN
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Volume of the periodical
77
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
835-843
UT code for WoS article
000294537000011
EID of the result in the Scopus database
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