Early regression of the dental lamina underlies the development of diphyodont dentitions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F12%3A00102393" target="_blank" >RIV/00843989:_____/12:00102393 - isvavai.cz</a>
Alternative codes found
RIV/67985904:_____/12:00379143 RIV/62157124:16170/12:43871657
Result on the web
<a href="http://dx.doi.org/10.1177/0022034512442896" target="_blank" >http://dx.doi.org/10.1177/0022034512442896</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/0022034512442896" target="_blank" >10.1177/0022034512442896</a>
Alternative languages
Result language
angličtina
Original language name
Early regression of the dental lamina underlies the development of diphyodont dentitions
Original language description
Functional tooth germs in mammals, reptiles, and chondrichthyans are initiated from a dental lamina. The longevity of the lamina plays a role in governing the number of tooth generations. Monophyodont species have no replacement dental lamina, while polyphyodont species have a permanent continuous lamina. In diphyodont species, the dental lamina fragments and regresses after initiation of the second tooth generation. Regression of the lamina seems to be an important mechanism in preventing the further development of replacement teeth. Defects in the complete removal of the lamina lead to cyst formation and has been linked to ameloblastomas. Here, we show the previously unknown mechanisms behind the disappearance of the dental lamina, involving a combination of cell migration, cell-fate transformation, and apoptosis. Lamina regression starts with the loss of the basement membrane, allowing the epithelial cells to break away from the lamina and migrate into the surrounding mesenchyme. Ce
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/KJB601110910" target="_blank" >KJB601110910: Developmental and evolutionary aspects of polyphyodont and heterodont dentition in reptiles</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of dental research
ISSN
0022-0345
e-ISSN
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Volume of the periodical
91
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
491-498
UT code for WoS article
000302916300010
EID of the result in the Scopus database
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