KOMET: an unblinded, randomised, two parallel-group, stratified trial comparing the effectiveness of levetiracetam with controlled-release carbamazepine and extended-release sodium valproate as monotherapy in patients with newly diagnosed epilepsy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F13%3AE0103556" target="_blank" >RIV/00843989:_____/13:E0103556 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1136/jnnp-2011-300376" target="_blank" >http://dx.doi.org/10.1136/jnnp-2011-300376</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/jnnp-2011-300376" target="_blank" >10.1136/jnnp-2011-300376</a>
Alternative languages
Result language
angličtina
Original language name
KOMET: an unblinded, randomised, two parallel-group, stratified trial comparing the effectiveness of levetiracetam with controlled-release carbamazepine and extended-release sodium valproate as monotherapy in patients with newly diagnosed epilepsy
Original language description
Objective: To compare the effectiveness of levetiracetam (LEV) with extended-release sodium valproate (VPA-ER) and controlled-release carbamazepine (CBZ-CR) as monotherapy in patients with newly diagnosed epilepsy. Methods: This unblinded, randomised, 52-week superiority trial (NCT00175903) recruited patients (16years of age) with 2 unprovoked seizures in the previous 2years and 1 in the previous 6months. The physician chose VPA or CBZ as preferred standard treatment; each patient was randomised to standard treatment or LEV. The primary outcome was time to treatment withdrawal (LEV vs standard antiepileptic drugs (AEDs)). Analyses also compared LEV with VPA-ER, and LEV with CBZ-CR. Findings: 1688 patients (mean age 41years; 44% female) were randomisedto LEV (n=841) or standard AEDs (n=847). Time to treatment withdrawal was not significantly different between LEV and standard AEDs: HR (95% CI) 0.90 (0.74 to 1.08). Time to treatment withdrawal (HR (95% CI)) was 1.02 (0.74 to 1.41) for L
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neurology, Neurosurgery and Psychiatry
ISSN
0022-3050
e-ISSN
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Volume of the periodical
84
Issue of the periodical within the volume
n. 10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
"p. 1138-1147"
UT code for WoS article
000323779800017
EID of the result in the Scopus database
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