Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F13%3AE0103633" target="_blank" >RIV/00843989:_____/13:E0103633 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/13:A14019L3 RIV/65269705:_____/13:#0002092 RIV/00216224:14110/13:00065642
Result on the web
<a href="http://dx.doi.org/10.1111/bjh.12563" target="_blank" >http://dx.doi.org/10.1111/bjh.12563</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/bjh.12563" target="_blank" >10.1111/bjh.12563</a>
Alternative languages
Result language
angličtina
Original language name
Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma
Original language description
Multiple myeloma (MM) is a haematological malignancy characterized by the accumulation of clonal plasma cells (PCs) in the bone marrow (BM). Although novel therapeutic strategies have prolonged survival of patients, the disease remains difficult to treatwith a high risk of relapse. The failure of therapy is thought to be associated with a persistent population of the so-called MM stem cells or myeloma initiating cells (MIC) that exhibit tumour-initiating potential, self-renewal and resistance to chemotherapy. However, the population responsible for the origin and sustainability of tumour mass has not been clearly characterized so far. This review summarizes current myeloma stem cell concepts and suggests that high phenotypic and intra-clonal heterogeneity, together with plasticity potential of MM might be other contributing factors explaining discrepancies among particular concepts and contributing to the treatment failure
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
British journal of haematology
ISSN
0007-1048
e-ISSN
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Volume of the periodical
163
Issue of the periodical within the volume
n. 5
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
"p. 551-564"
UT code for WoS article
000326807400003
EID of the result in the Scopus database
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