Granulocyte colony-stimulating factor in patients with acute ischemic stroke results of the AX200 for ischemic stroke trial
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F13%3AE0103703" target="_blank" >RIV/00843989:_____/13:E0103703 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/13:A1401AZE RIV/61989592:15120/13:33149366
Result on the web
<a href="http://dx.doi.org/10.1161/STROKEAHA.113.001531" target="_blank" >http://dx.doi.org/10.1161/STROKEAHA.113.001531</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1161/STROKEAHA.113.001531" target="_blank" >10.1161/STROKEAHA.113.001531</a>
Alternative languages
Result language
angličtina
Original language name
Granulocyte colony-stimulating factor in patients with acute ischemic stroke results of the AX200 for ischemic stroke trial
Original language description
Background and Purpose: Granulocyte colony-stimulating factor (G-CSF; AX200; Filgrastim) is a stroke drug candidate with excellent preclinical evidence for efficacy. A previous phase IIa dose-escalation study suggested potential efficacy in humans. The present large phase IIb trial was powered to detect clinical efficacy in acute ischemic stroke patients. Methods: G-CSF (135 mu g/kg body weight intravenous over 72 hours) was tested against placebo in 328 patients in a multinational, multicenter, randomized, and placebo-controlled trial (NCT00927836; www.clinicaltrial.gov). Main inclusion criteria were 9-hour time window after stroke onset, infarct localization in the middle cerebral artery territory, baseline National Institutes of Health Stroke Scalescore range of 6 to 22, and baseline diffusion-weighted imaging lesion size 15 mL. Primary and secondary end points were the modified Rankin scale score and the National Institutes of Health Stroke Scale score at day 90, respectively. Dat
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Stroke
ISSN
0039-2499
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
n. 10
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
"p. 2681-2687"
UT code for WoS article
000324831900018
EID of the result in the Scopus database
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