Pelvic lymphadenectomy improves survival in patients with cervical cancer with low-volume disease in the sentinel node

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F14%3AE0103887" target="_blank" >RIV/00843989:_____/14:E0103887 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1097/IGC.0000000000000043" target="_blank" >http://dx.doi.org/10.1097/IGC.0000000000000043</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/IGC.0000000000000043" target="_blank" >10.1097/IGC.0000000000000043</a>

Result language
angličtina
Original language name
Pelvic lymphadenectomy improves survival in patients with cervical cancer with low-volume disease in the sentinel node
Original language description
OBJECTIVE: In this study, we aimed to describe the value of pelvic lymph node dissection (LND) after sentinel lymph node (SN) biopsy in early-stage cervical cancer. METHODS: We performed a retrospective multicenter cohort study in 8 gynecological oncology departments. In total, 645 women with International Federation of Gynecology and Obstetrics stage IA to IIB cervical cancer of squamous, adeno, or adenosquamous histologic type who underwent SN biopsy followed by pelvic LND were enrolled in this study.Radioisotope tracers and blue dye were used to localize the sentinel node, and pathologic ultrastaging was performed. RESULTS: Among the patients with low-volume disease (micrometastases and isolated tumor cells) in the sentinel node, the overall survival was significantly better (P = 0.046) if more than 16 non-SNs were removed. No such significant difference in survival was detected in patients with negative or macrometastatic sentinel nodes. CONCLUSIONS: Our findings indicate that in
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FK - Gynaecology and obstetrics
OECD FORD branch
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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