Varespladib and cardiovascular events in patients with an acute coronary syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F14%3AE0103893" target="_blank" >RIV/00843989:_____/14:E0103893 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1001/jama.2013.282836" target="_blank" >http://dx.doi.org/10.1001/jama.2013.282836</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1001/jama.2013.282836" target="_blank" >10.1001/jama.2013.282836</a>
Alternative languages
Result language
angličtina
Original language name
Varespladib and cardiovascular events in patients with an acute coronary syndrome
Original language description
IMPORTANCE Secretory phospholipase A(2) (sPLA(2)) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA2 inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes is unknown. OBJECTIVE To determine the effects of sPLA2 inhibition with varespladib on cardiovascular outcomes. DESIGN, SETTING, AND PARTICIPANTS A double-blind, randomized, multicenter trial at 362 academic and community hospitals in Europe, Australia, New Zealand, India, and North America of 5145 patients randomized within 96 hours of presentation of an acute coronary syndrome (ACS) to either varespladib (n = 2572) or placebo (n = 2573) with enrollment between June 1, 2010, and March 7, 2012 (study termination on March 9, 2012). INTERVENTIONS Participants were randomized to receive varespladib (500 mg) or placebo daily for 16 weeks, in addition to atorvastatin and other established therapies. MAIN OUTCOMES AND MEASURES The primar
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JAMA
ISSN
0098-7484
e-ISSN
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Volume of the periodical
311
Issue of the periodical within the volume
n. 3
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
"p. 252-262"
UT code for WoS article
000329566400017
EID of the result in the Scopus database
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