<A >prokinetic agent with a dual effect - itopride - in the treatment of dysmotility
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F14%3AE0104289" target="_blank" >RIV/00843989:_____/14:E0104289 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/14:A1501CGZ
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
<A >prokinetic agent with a dual effect - itopride - in the treatment of dysmotility
Original language description
A wide range of dyspeptic symptoms in clinical practice reflect the high prevalence of functional disorders of the gastrointestinal (GI) tract. Prokinetic agents are the current mainstay in the therapy of functional dyspepsia. One of these drugs is itopride. We evaluated therapeutic efficacy of itopride according to the literature review. The therapeutic potential of itopride is connected with a dual effect: influencing of enzyme acetylcholinesterase activity and blocking dopamine D2 receptors. After the itopride administration, the contractility of smooth muscle in the upper GI tract increases. Itopride is a drug with rapid absorption from the small bowel; its peak serum concentration occurs 35 minutes after oral administration. Itopride does not passthe blood-brain barrier and does not affect the heart rate by influencing the QT segment. Itopride is a safe prokinetic agent with positive influence on the symptoms of functional dyspepsia such as postprandial fullness, bloating, and ga
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European medical journal. Gastroenterology
ISSN
2054-6203
e-ISSN
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Volume of the periodical
3
Issue of the periodical within the volume
n. December
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
"p. 42-47"
UT code for WoS article
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EID of the result in the Scopus database
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