Sonolysis in prevention of brain infarction during cardiac surgery (SONORESCUE)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F16%3AE0105503" target="_blank" >RIV/00843989:_____/16:E0105503 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1097/MD.0000000000003615" target="_blank" >http://dx.doi.org/10.1097/MD.0000000000003615</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MD.0000000000003615" target="_blank" >10.1097/MD.0000000000003615</a>

Result language

angličtina

Original language name

Sonolysis in prevention of brain infarction during cardiac surgery (SONORESCUE)

Original language description

Here, we examined whether intraoperative sonolysis can alter the risk of new ischemic lesions in the insonated brain artery territory during coronary artery bypass grafting (CABG) or valve surgery.Silent brain ischemic lesions could be detected in as many as two-thirds of patients after CABG or valve surgery.Patients indicated for CABG or valve surgery were allocated randomly to sonolysis (60 patients, 37 males; mean age, 65.3 years) of the right middle cerebral artery (MCA) during cardiac surgery and control group (60 patients, 37 males; mean age, 65.3 years). Neurologic examination, cognitive function tests, and brain magnetic resonance imaging (MRI) were conducted before intervention as well as 24 to 72?hours and 30 days after surgery.New ischemic lesions on control diffusion-weighted MRI in the insonated MCA territory ?0.5?mL were significantly less frequent in the sonolysis group than in the control group (13.3% vs 26.7%, P?=?0.109). The sonolysis group exhibited significantly reduced median volume of new brain ischemic lesions (P?=?0.026). Stenosis of the internal carotid artery ?50% and smoking were independent predictors of new brain ischemic lesions ?0.5?mL (odds ratio?=?5.685 [1.272-25.409], P?=?0.023 and 4.698 [1.092-20.208], P?=?0.038, respectively). Stroke or transient ischemic attack occurred only in 2 control patients (P?=?0.496). No significant differences were found in scores for postintervention cognitive tests (P?>?0.05).This study provides class-II evidence that sonolysis during CABG or valve surgery reduces the risk of larger, new ischemic lesions in the brain

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NT13498" target="_blank" >NT13498: Risk reduction of symptomatic and silent brain infarctions during cardiac surgery due to ultrasound activation of endogenous fibrinolytic system using transcranial Doppler monitoring</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medicine

ISSN

0025-7974

e-ISSN

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Volume of the periodical

95

Issue of the periodical within the volume

n. 20

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

"p. 1-7"

UT code for WoS article

000377777200025

EID of the result in the Scopus database

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