Aggressive extraocular sebaceous carcinoma of the scalp involving the brain in a patient with Muir-Torre syndrome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F16%3AE0105593" target="_blank" >RIV/00843989:_____/16:E0105593 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/16:10316662 RIV/61988987:17110/16:A20020XG

Result on the web

<a href="http://dx.doi.org/10.1097/DAD.0000000000000524" target="_blank" >http://dx.doi.org/10.1097/DAD.0000000000000524</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/DAD.0000000000000524" target="_blank" >10.1097/DAD.0000000000000524</a>

Result language

angličtina

Original language name

Aggressive extraocular sebaceous carcinoma of the scalp involving the brain in a patient with Muir-Torre syndrome

Original language description

This article reports an unusual case of aggressive extraocular sebaceous carcinoma located on the scalp with subsequent usurpation of the bone and penetrating through the bone and meninges to the brain in a 56-year-old man affected by Muir-Torre syndrome. Microscopically, the sebaceous neoplasm was located in the middle to deep dermis without any connection to the epidermis and showed a multinodular growth with neoplastic nodules with a central comedo-type necrosis separated from each other by fibrovascular stroma. The nodules were composed of varying proportions of mature sebaceous cells and atypical basaloid cells with high degree of atypia, including high nuclear/cytoplasmic ratio, nuclear pleomorphism, macronucleoli, atypical mitoses, and necrosis. The neoplasm was totally removed. Histopathological examinations of the recurrent lesion showed identical morphological features and, in addition, signs of the tumors growing through the periosteum were noted. In the final excision specimen, both the dura mater and the brain tissue were infiltrated by the sebaceous carcinoma. The diagnosis of Muir-Torre syndrome was confirmed by molecular genetic investigation that revealed an identical germline mutation in MSH2 gene in several family members, some of whom had colorectal tumors.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

American Journal of Dermatopathology

ISSN

0193-1091

e-ISSN

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Volume of the periodical

38

Issue of the periodical within the volume

n. 8

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

"p. 618-622"

UT code for WoS article

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EID of the result in the Scopus database

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