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Diagnostic tools of Waldenström ´s macroglobulinemia - best possibilities for non-invasive and long-term disease monitoring

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F17%3AE0106567" target="_blank" >RIV/00843989:_____/17:E0106567 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.14735/amko20172S81" target="_blank" >http://dx.doi.org/10.14735/amko20172S81</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.14735/amko20172S81" target="_blank" >10.14735/amko20172S81</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Diagnostic tools of Waldenström ´s macroglobulinemia - best possibilities for non-invasive and long-term disease monitoring

  • Original language description

    Waldenström’s macroglobulinemia (WM) is a B-cell malignancy characterized by high level of monoclonal immunoglobulin M (IgM) paraprotein in blood serum and associated with the bone marrow infiltration by malignant cells with lymphoplasmacytic differentiation. WM remains incurable advances in therapy. Most of WM cases are associated with a somatic point mutation L265P in MYD88. Significantly higher risk of progression from the IgM monoclonal gammopathy of undetermined significance (IgM MGUS) to WM for patients with mutated MYD88 gene suggests that this mutation is an early oncogenic event and plays a central role in development of malignant clones. The second, most prevalent mutation in WM is found in the CXCR4 gene and is often associated with drug resistance and aggressive disease presentation. Therefore, detection of these mutations (MYD88L265P and CXCR4S338X) could be useful diagnostic and prognostic tool for the patients with WM. While detection of these mutations in bone marrow sample is common, the aim of our study was to compare sensitivity of detection of mutation from different cell fraction from peripheral blood and bone marrow. The results show possibility to describe MYD88 and CXCR4 mutation status even from peripheral blood sample (sensitivity for MYD88L265P was 100%, for CXCR4S338X 91%), which significantly facilitate material collection. Moreover, comparable detection sensitivity of these mutations in bone marrow and peripheral blood samples examined before and during the therapy offers a promising tool for more routine diagnostic and monitoring of disease progression.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Klinická onkologie

  • ISSN

    0862-495X

  • e-ISSN

    1802-5307

  • Volume of the periodical

    30

  • Issue of the periodical within the volume

    suppl.2

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    1

  • Pages from-to

    2s81-2s91

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-85029470000