Serum cytokine and growth factor levels in children with autism spectrum disorder
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F18%3AE0107059" target="_blank" >RIV/00843989:_____/18:E0107059 - isvavai.cz</a>
Result on the web
<a href="https://www.medscimonit.com/abstract/index/idArt/906817" target="_blank" >https://www.medscimonit.com/abstract/index/idArt/906817</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.12659/MSM.906817" target="_blank" >10.12659/MSM.906817</a>
Alternative languages
Result language
angličtina
Original language name
Serum cytokine and growth factor levels in children with autism spectrum disorder
Original language description
Background: The immune system may have a role in the pathogenesis of autism spectrum disorder (ASD), including typical and atypical autism. The aim of this study was to determine whether a cytokine and growth factor panel could be identified for the diagnosis and prognosis in children with ASD, including typical and atypical autism. Material/Methods: This study included 26 children with ASD (typical or atypical) and 11 of their siblings who did not have ASD. A panel often serum cytokines and growth factors were investigated using addressable laser bead assay (ALBIA) and enzyme-linked immunosorbent assay (ELISA) kits. Results were correlated with scores using the Childhood Autism Rating Scale (CARS) and Autism Diagnostic Observation Schedule (ADOS) for the children with ASD and compared with the findings from their siblings without ASD. Results: There were no statistically significant differences in serum cytokine and growth factor levels between children with ASD and their siblings. The scores using CARS and ADOS were significantly greater in children with typical autism compared with children with atypical autism as part of the ASD spectrum. Serum levels of cytokines and growth factors showed a positive correlation with CARS and ADOS scores but differed between children with typical and atypical autism and their siblings. Conclusions: The findings of this study showed that serum measurement of appropriately selected panels of cytokines and growth factors might have a role in the diagnosis of ASD.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medical science monitor
ISSN
1234-1010
e-ISSN
1643-3750
Volume of the periodical
24
Issue of the periodical within the volume
april
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
2639-2646
UT code for WoS article
000431079700001
EID of the result in the Scopus database
2-s2.0-85046637977