Factors that predict the growth of residual nonfunctional pituitary adenomas: correlations between relapse and cell cycle markers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F18%3AE0107199" target="_blank" >RIV/00843989:_____/18:E0107199 - isvavai.cz</a>

Result on the web

<a href="https://www.hindawi.com/journals/bmri/2018/1876290/" target="_blank" >https://www.hindawi.com/journals/bmri/2018/1876290/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2018/1876290" target="_blank" >10.1155/2018/1876290</a>

Result language

angličtina

Original language name

Factors that predict the growth of residual nonfunctional pituitary adenomas: correlations between relapse and cell cycle markers

Original language description

Introduction. Nonfunctional pituitary adenomas are treated surgically, and even partial resection can improve or eliminate clinical symptoms. Notably, progression requires further intervention, which presents an increased risk, especially in older patients. This study investigated whether the histopathological characteristics of nonfunctional adenomas could predict recurrence. Materials and Methods. Data were obtained retrospectively from 30 patients who underwent surgery for the partial resection of pituitary adenomas. Remnant tumor growth was observed in 17 patients, while the residual tumor was unchanged more than 7 years after surgery in 13 patients. Statistical analysis was performed to investigate correlations between remnant tumor progression and tumor histopathological findings, including protein expression of p21, p27, p53, and Ki-67. Results and Discussion. Remnant tumors that demonstrated regrowth showed significantly higher protein expression of p21 and Ki-67. Expression of the p53 tumor suppressor was also higher in this group, but the difference was at the limit of statistical significance. Conclusion. Tumors with high expression of p21 and p53 and with a high Ki-67 index were more likely to show residual pituitary adenoma progression. Such cases should undergo frequent radiological examination and timely reoperation, and radiosurgery should be considered.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BioMed research international

ISSN

2314-6133

e-ISSN

2314-6141

Volume of the periodical

2018

Issue of the periodical within the volume

article id 1876290

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

1-9

UT code for WoS article

000439226400001

EID of the result in the Scopus database

2-s2.0-85050907080