Dexamethasone reduces the incidence of postoperative nausea and vomiting in children undergoing endoscopic adenoidectomy under general anesthesia without increasing the risk of postoperative hemorrhage

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F18%3AE0107329" target="_blank" >RIV/00843989:_____/18:E0107329 - isvavai.cz</a>

Result on the web

<a href="https://www.medscimonit.com/abstract/index/idArt/911231" target="_blank" >https://www.medscimonit.com/abstract/index/idArt/911231</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.12659/MSM.911231" target="_blank" >10.12659/MSM.911231</a>

Result language

angličtina

Original language name

Dexamethasone reduces the incidence of postoperative nausea and vomiting in children undergoing endoscopic adenoidectomy under general anesthesia without increasing the risk of postoperative hemorrhage

Original language description

BACKGROUND: Postoperative nausea and vomiting (PONV) is a common complication of pediatric anesthesia, but the overall incidence of PONV in patients undergoing adenoidectomy is unknown. The aim of this controlled study was to compare the effect of dexamethasone administration with placebo to reduce PONV in children undergoing endoscopic adenoidectomy under general anesthesia. MATERIAL AND METHODS: A randomized placebo-controlled study included 118 pediatric patients who underwent elective endoscopic adenoidectomy under general anesthesia. A dexamethasone-treated (0.15 mg/kg) group (Group D) (n=56) and a placebo group (Group C) (n=62) were randomly assigned. The incidence of nausea and vomiting was recorded on the day of surgery. Postoperative nausea was assessed according to illustrated Baxter Animated Retching Faces (BARF) scale. The Face, Legs, Activity, Cry, and Consolability (FLACC) scale (scores between 0–10) was used to assess pain. Follow-up was performed on the 14th postoperative day by a telephone call. RESULTS: Overall prevalence of postoperative nausea was 25% (30/118) and postoperative vomiting was 14% (17/118). In the first 24 hours following surgery, in Group D, the incidence of nausea and vomiting was 13% and 7%, respectively; in Group C, without pharmacological prophylaxis, the incidence of postoperative nausea and vomiting was 37%, and 21%, respectively. CONCLUSIONS: A prospective controlled study in children undergoing endoscopic adenoidectomy under general anesthesia showed that dexamethasone (0.15 mg/kg) significantly reduced the incidence of PONV without increasing the risk of postoperative hemorrhage. Dexamethasone is a safe method for the prevention of PONV that may be recommended in pediatric anesthesiology.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30223 - Anaesthesiology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medical science monitor

ISSN

1234-1010

e-ISSN

1643-3750

Volume of the periodical

24

Issue of the periodical within the volume

nov 22

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

8430-8438

UT code for WoS article

000451039400003

EID of the result in the Scopus database

2-s2.0-85057135772