Autistic spectrum disorder: what video EEG can reveal about its pathophysiology

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F18%3AE0107559" target="_blank" >RIV/00843989:_____/18:E0107559 - isvavai.cz</a>

Result on the web

<a href="https://www.omicsonline.org/open-access/autistic-spectrum-disorder-what-video-eeg-can-reveal-about-its-pathophysiology-2165-7890-1000234-106292.html" target="_blank" >https://www.omicsonline.org/open-access/autistic-spectrum-disorder-what-video-eeg-can-reveal-about-its-pathophysiology-2165-7890-1000234-106292.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4172/2165-7890.1000234" target="_blank" >10.4172/2165-7890.1000234</a>

Result language

angličtina

Original language name

Autistic spectrum disorder: what video EEG can reveal about its pathophysiology

Original language description

Objective: The autistic spectrum disorder (ASD) is a lifelong disorder characterized by a defect in communication, social interaction and stereotype patterns of behavior. The etiology of ASD is probably heterogenous. EEG abnormalities were observed in autistic patients, but these findings are mostly based on the visual analysis and scarce studies used quantified EEG parameters. Changes in connectivity of various parts of brain cortex were described in some studies and that is why we decided to investigate an EEG measure which is capable to evaluate the connectivity: The coherence. Study aims are to, 1. Assess the hypothesis of connectivity changes; 2. Assess the impact of epileptiform discharges on neuropsychological development. Methods: We present a small study of 24 children with ASD who underwent complex neuropsychological, neurological, sleep video-EEG (whole night and part-day) and MRI of brain investigations. The video EEG and MRI data are compared with quasi-normal EEG and MRI data from the control group. The EEG data were evaluated by experienced EEG reader and then the parts of EEG in relaxed wakefulness were quantified in terms of inter-channel coherence in several EEG channels. Results: A coherence analysis across several EEG channels revealed a statistically significant correlation between inter hemispheric coherence of the rear temporal regions (T5-T6) at 16-31 Hz and Childhood Autism Rating Scale raw scores. Conclusion: The changes in connectivity measured by the coherence might be a part of pathophysiology of the ASD.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Autism - Open Access

ISSN

2165-7890

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

4

Country of publishing house

IN - INDIA

Number of pages

4

Pages from-to

1-4

UT code for WoS article

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EID of the result in the Scopus database

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