Laryngopharyngeal reflux is a potential risk factor for juvenile-onset recurrent respiratory papillomatosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F19%3AE0107663" target="_blank" >RIV/00843989:_____/19:E0107663 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/19:00109468
Result on the web
<a href="https://www.hindawi.com/journals/bmri/2019/1463896/" target="_blank" >https://www.hindawi.com/journals/bmri/2019/1463896/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2019/1463896" target="_blank" >10.1155/2019/1463896</a>
Alternative languages
Result language
angličtina
Original language name
Laryngopharyngeal reflux is a potential risk factor for juvenile-onset recurrent respiratory papillomatosis
Original language description
Introduction. Human papillomavirus (HPV) causes juvenile-onset recurrent respiratory papillomatosis (JORRP). Although HPV is common in children, the prevalence of JORRP is low. It is likely that other factors contribute to the pathogenesis of JORRP, during either activation or reactivation of a latent HPV infection. There is evidence that laryngopharyngeal reflux (LPR) might be such a risk factor for adult-onset recurrent respiratory papillomatosis. This study investigated if LPR might also be a risk factor for JORRP. Materials and Methods. Children with JORRP of the larynx that required microlaryngoscopy at a tertiary referral hospital were included in this prospective case-series study from November 2015 to November 2017. Using immunohistochemistry, HPV infection and pepsin associated with LPR were diagnosed from laryngeal biopsies. Results. Eleven children (aged 4-14 years) were analyzed. No patient had a history of immunodeficiency or tobacco smoke exposure. All patients underwent at least three previous surgeries due to JORRP and had been vaccinated against HPV in the past. Five children were treated using antivirotics and immunomodulators. The only known maternal risk factor was that three mothers were primiparous. All 11 samples were infected with HPV (type 6 or 11). Pathologic LPR was diagnosed in 5/11 children (45.5%). Conclusion. LPR may be a risk factor for JORRP, contributing to its development by activating or reactivating a latent HPV infection. Results are in accordance with those from our previous study in adults.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30206 - Otorhinolaryngology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BioMed research international
ISSN
2314-6133
e-ISSN
2314-6141
Volume of the periodical
2019
Issue of the periodical within the volume
article id 1463896
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
1-5
UT code for WoS article
000459656800001
EID of the result in the Scopus database
2-s2.0-85062348102