Cardiac strains as a tool for optimization of cardiac resynchronization therapy in non-responders: a pilot study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F19%3AE0108236" target="_blank" >RIV/00843989:_____/19:E0108236 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/19:00112594 RIV/65269705:_____/19:00071838
Result on the web
<a href="https://www.degruyter.com/downloadpdf/j/med.2019.14.issue-1/med-2019-0111/med-2019-0111.pdf" target="_blank" >https://www.degruyter.com/downloadpdf/j/med.2019.14.issue-1/med-2019-0111/med-2019-0111.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/med-2019-0111" target="_blank" >10.1515/med-2019-0111</a>
Alternative languages
Result language
angličtina
Original language name
Cardiac strains as a tool for optimization of cardiac resynchronization therapy in non-responders: a pilot study
Original language description
Background: Approximately 30% of patients do not respond to implantation of Cardiac Resynchronization Therapy – Defibrillators (CRT-D). The aim of this study was to investigate the potential for cardiac strain speckle tracking to optimize the performance of CRT-D in non-responding patients. Methods: 30 patients not responding to Cardiac Resynchronization Therapy-Defibrillators after 3 months were randomly divided into control and intervention groups. Atrioventricular interval was adjusted so that E and A waves did not overlap, the interventricular interval was subsequently optimized to yield maximum improvement of the sum of longitudinal+radial+circumferential strains. The left ventricular ejection fraction (LVEF) and NYHA improvement 3 months after optimization were evaluated and use of other strain combinations assessed. Results: A significant correlation between the (combined) strain change and LVEF improvement was detected (p<0.01). 75% of patients with non-ischemic etiology of heart failure who did not respond to the original CRT-D reacted favorably with significant LVEF and NYHA improvement. The area strain was the best predictor of LVEF/NYHA improvement in those patients. No significant improvement was recorded in patients with ischemic etiology. Conclusions: AV and VV optimization based on speckle tracking is a very promising method potentially leading to a significant improvement of the outcome of CRT-D, especially in patients with non-ischemic etiology of heart failure.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Open Medicine
ISSN
2391-5463
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
1
Country of publishing house
PL - POLAND
Number of pages
8
Pages from-to
945-952
UT code for WoS article
000501996200002
EID of the result in the Scopus database
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