Death in hospital following ICU discharge: insights from the LUNG SAFE study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F21%3AE0108928" target="_blank" >RIV/00843989:_____/21:E0108928 - isvavai.cz</a>

Result on the web

<a href="https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-021-03465-0.pdf" target="_blank" >https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-021-03465-0.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13054-021-03465-0" target="_blank" >10.1186/s13054-021-03465-0</a>

Result language

angličtina

Original language name

Death in hospital following ICU discharge: insights from the LUNG SAFE study

Original language description

Background: To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Methods: The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments ('treatment limitations'), and the subpopulations with treatment limitations. Results: 2186 (94%) patients with no treatment limitations discharged from ICU survived, while 142 (6%) died in hospital. 118 (61%) of patients with treatment limitations survived while 77 (39%) patients died in hospital. Patients without treatment limitations that died in hospital after ICU discharge were older, more likely to have COPD, immunocompromise or chronic renal failure, less likely to have trauma as a risk factor for ARDS. Patients that died post ICU discharge were less likely to receive neuromuscular blockade, or to receive any adjunctive measure, and had a higher pre- ICU discharge non-pulmonary SOFA score. A similar pattern was seen in patients with treatment limitations that died in hospital following ICU discharge. Conclusions: A significant proportion of patients die in hospital following discharge from ICU, with higher mortality in patients with limitations of life-sustaining treatments in place. Non-survivors had higher systemic illness severity scores at ICU discharge than survivors. Trial registration: ClinicalTrials.gov NCT02010073 .

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30221 - Critical care medicine and Emergency medicine

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Critical care

ISSN

1364-8535

e-ISSN

1466-609X

Volume of the periodical

21

Issue of the periodical within the volume

144)

Country of publishing house

GB - UNITED KINGDOM

Number of pages

17

Pages from-to

1-17

UT code for WoS article

000640238900004

EID of the result in the Scopus database

2-s2.0-85104354190