Health of children born to childhood cancer survivors: Participant characteristics and methods of the Multicenter Offspring Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F21%3AE0109217" target="_blank" >RIV/00843989:_____/21:E0109217 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/21:00075486 RIV/00179906:_____/21:10433204 RIV/00064203:_____/21:10433204 RIV/00216208:11130/21:10433204

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1877782121001697" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1877782121001697</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.canep.2021.102052" target="_blank" >10.1016/j.canep.2021.102052</a>

Result language

angličtina

Original language name

Health of children born to childhood cancer survivors: Participant characteristics and methods of the Multicenter Offspring Study

Original language description

Introduction: Research on childhood cancer survivor offspring has been limited to genetic disease occurrence, malformations or non-hereditary cancers. However, previous surveys indicated that survivors harbor fears about their (prospective) children's overall health. Our Multicenter Offspring Study examined extensive health aspects in children born to survivors and their siblings providing comprehensive information to be used in patient counseling to elucidate and alleviate existing concerns. Methods: Using a specifically designed questionnaire, childhood cancer survivors and their siblings were surveyed on their offspring's health (Supplementary material). Recruitment strategies depended on local infrastructures and standards of participating centers, including registry-based and direct approaches. Group differences were tested non-parametrically and effect sizes were calculated. Results: In total, 1126 survivors reported on 1780 offspring and 271 siblings reported on 441 offspring. Response rates ranged from 32.1% (Czech Republic) to 85.0% (Austria). Respondents were more likely to be female (p = .007), older at time of survey (p < .001), diagnosed 1980-1999 (p < .001) and treated with chemotherapy (p < .001). Compared to siblings, survivors were younger at time of survey (35 years vs. 39 years, p < .001) and at first birth (29 years vs. 30 years, p < .001). Survivor and sibling offspring only differed in terms of age at survey (6.3 years vs. 8.9 years, p < .001). Conclusion: The Multicenter Offspring Study investigates a wide variety of health aspects in offspring born to survivors and their siblings in five European countries. Our study cohorts form a solid basis for future analyses; yet, certain limitations, due to differences in approach among participating centers, must be considered when interpreting findings.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30209 - Paediatrics

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer epidemiology

ISSN

1877-7821

e-ISSN

1877-783X

Volume of the periodical

74

Issue of the periodical within the volume

article 102052

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

1-9

UT code for WoS article

000712439800004

EID of the result in the Scopus database

2-s2.0-85117925507