Directly measured adherence to treatment in chronic heart failure: LEVEL-CHF Registry
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F21%3AE0109480" target="_blank" >RIV/00843989:_____/21:E0109480 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/21:N0000096 RIV/61989592:15110/21:73607144 RIV/00216224:14110/21:00122111
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0002962920305371?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0002962920305371?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.amjms.2020.12.004" target="_blank" >10.1016/j.amjms.2020.12.004</a>
Alternative languages
Result language
angličtina
Original language name
Directly measured adherence to treatment in chronic heart failure: LEVEL-CHF Registry
Original language description
Background: Currently, most available data on the medication adherence of patients with chronic heart failure are based on indirect methods. We examined the level of adherence to medical therapy using a direct method - serum drug level testing. Methods: We carried out a prospective single-centre registry of patients with chronic heart failure (LEVEL-CHF registry), in whom we analysed serum levels of the medications prescribed for the treatment of heart failure: angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers and mineralocorticoid receptor antagonists. We labelled a patient as non-adherent if at least one serum level of a prescribed drug was unmeasurable (below the detection limit). Patients with all tested drugs identifiable in serum were labelled as adherent. We enrolled 274 patients (208 men and 66 women) mean age 62 years. Results: 82.5% of patients were adherent and 17.5% non-adherent to prescribed medications. 3.6% were completely non-adherent without any detectable drugs in serum. Patients aged <60 years were more likely to be non-adherent than older patients (OR 2.15). No other clinical or laboratory parameters predicted non-adherence. Conclusions: A significant proportion of outpatients with chronic heart failure were non-adherent to treatment when assessed by a direct method of serum drug level testing. Non-adherence was more likely in younger patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American journal of the medical sciences
ISSN
0002-9629
e-ISSN
1538-2990
Volume of the periodical
361
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
491-498
UT code for WoS article
000637866100016
EID of the result in the Scopus database
2-s2.0-85103432086