Was it necessary to change the therapeutic range of topiramate?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F22%3AE0109458" target="_blank" >RIV/00843989:_____/22:E0109458 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/22:A2302BQG
Result on the web
<a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.14985" target="_blank" >https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.14985</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/bcp.14985" target="_blank" >10.1111/bcp.14985</a>
Alternative languages
Result language
angličtina
Original language name
Was it necessary to change the therapeutic range of topiramate?
Original language description
Aims: The Norwegian Association for Clinical Pharmacology in their National Guidelines decreased the therapeutic range (TR) of topiramate (TPM) from 5-20 mg/L to 2-10 mg/L. The objective of this study is to ascertain which TR produces better clinical outcomes. Methods: The data sources were request forms for routine therapeutic drug monitoring (TDM) of TPM. Concentration dependent adverse drug reactions (ADRs) were evaluated in 1721 samples taken pre-dose. Seizure frequency analysis was performed in 294 samples of monotherapy. Statistical analysis was performed using Prism 5.0, GraphPad Instatt: One-way ANOVA with Bonferroni correction for median plasma level (PL) and ?2 -test with Bonferroni correction for seizure frequency and for distribution of PL according to TR 5-20 mg/L and intervals <2, 2-5, 5-10, 10-20, >20 mg/L. Results: Better seizure control was found in children both in the whole cohort (without seizure 49% vs 37% adults), as well as in monotherapy (56% vs 44%), in children with PL 5-20 mg/L vs <5 mg/L (65% vs 44%) and in children with PL 5-10 mg/L vs <2 mg/L (63 vs 14%). PL in seizure-free patients did not differ from those with seizure. Seizure control was poorer in the period 2003-2005 compared to 2006-2011. ADRs reported in 38 samples (2.8%) were not related to PL. Conclusions: Change of TR is not recommended.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
British journal of clinical pharmacology
ISSN
0306-5251
e-ISSN
1365-2125
Volume of the periodical
88
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
613-618
UT code for WoS article
000681480300001
EID of the result in the Scopus database
2-s2.0-85111812955