Natural killer cells: Innate immune system as a part of adaptive immunotherapy in hematological malignancies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F22%3AE0109587" target="_blank" >RIV/00843989:_____/22:E0109587 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/22:A2302FTO
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/ajh.26529" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ajh.26529</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ajh.26529" target="_blank" >10.1002/ajh.26529</a>
Alternative languages
Result language
angličtina
Original language name
Natural killer cells: Innate immune system as a part of adaptive immunotherapy in hematological malignancies
Original language description
Natural killer (NK) cells are part of a phylogenetically old defense system, which is characterized by its strong cytolytic function against physiologically stressed cells such as tumor cells and virus-infected cells. Their use in the treatment of hematological malignancies may be more advantageous in several ways when compared with the already established T lymphocyte-based immunotherapy. Given the different mechanisms of action, allogeneic NK cell products can be produced in a non-personal based manner without the risk of the formidable graft-versus-host disease. Advanced manufacturing processes are capable of producing NK cells relatively easily in large and clinically sufficient numbers, useable without subsequent manipulations or after genetic modifications, which can solve the lack of specificity and improve clinical efficacy of NK cell products. This review summarizes the basic characteristics of NK cells and provides a quick overview of their sources. Results of clinical trials in hematological malignancies are presented, and strategies on how to improve the clinical outcome of NK cell therapy are discussed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American journal of hematology
ISSN
0361-8609
e-ISSN
1096-8652
Volume of the periodical
97
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
802-817
UT code for WoS article
000773282400001
EID of the result in the Scopus database
2-s2.0-85127266476