Clinical utility of ß3-adrenoreceptor agonists for the treatment of overactive bladder: a review of the evidence and current recommendations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F22%3AE0109589" target="_blank" >RIV/00843989:_____/22:E0109589 - isvavai.cz</a>

Result on the web

<a href="https://www.dovepress.com/getfile.php?fileID=80258" target="_blank" >https://www.dovepress.com/getfile.php?fileID=80258</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/RRU.S309144" target="_blank" >10.2147/RRU.S309144</a>

Result language

angličtina

Original language name

Clinical utility of ß3-adrenoreceptor agonists for the treatment of overactive bladder: a review of the evidence and current recommendations

Original language description

This nonsystematic review provides a summary of current evidence on the use of ß3-adrenoreceptor agonists (ß3-ARAs) for the treatment for lower urinary tract symptoms. Soon after their discovery in 1989, ß3-ARs were identified as a predominant adrenoreceptor subtype in the human urinary bladder. Although it is widely believed that ß3-ARAs cause detrusor relaxation, the effect on bladder afferent signaling likely plays an important role in their mechanism of action as well. In 2011 and 2012, mirabegron was approved for clinical use in overactive bladder (OAB) patients. Pooled analysis of data from prospective randomized studies on >60,000 OAB patients showed that when compared to placebo, mirabegron was superior with respect to reducing the frequency, number, and severity of urgency episodes, number of incontinence episodes and increasing dry rate, but not in reduction of nocturia episodes. The only side effect showing significantly higher incidence than placebo was nasopharyngitis. Mirabegron is approved for OAB treatment in all age-groups and in pediatric patients with neurogenic bladder. Vibegron is another ß3-ARA approved for OAB treatment in the US and Japan. Several large, multicenter, double-blind, randomized trials have documented statistically significant superiority of vibegron over placebo on all efficacy end points. Other ß3-ARAs are being developed; however, to date none has been introduced to clinical use. All ß3-ARAs provide efficacy similar to anticholinergics. They have a favorable safety profile and are well tolerated. Due to their different mechanisms of action, combination of ß3-ARAs with anticholinergic compounds allows for increased efficacy.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30217 - Urology and nephrology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Research and reports in urology

ISSN

2253-2447

e-ISSN

2253-2447

Volume of the periodical

14

Issue of the periodical within the volume

april

Country of publishing house

NZ - NEW ZEALAND

Number of pages

9

Pages from-to

167-175

UT code for WoS article

000802985400003

EID of the result in the Scopus database

2-s2.0-85129619568